cAMP-induced chemical kindling and transfer to electrical kindling.
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چکیده
منابع مشابه
Inhibitory effects of succinic acid on chemical kindling and amygdala electrical kindling in rats.
AIM To investigate the effects and mechanism of succinic acid on pentylenetetrazol (PTZ) chemical kindling and amygdala electrical kindling in rats. METHODS PTZ chemical kindling and amygdala electrical kindling models were established in rats. The effects of succinic acid on the behavior and afterdischarge of kindled rats were observed. The mice were pretreated with succinic acid, 30 min lat...
متن کاملLow Frequency Electrical Stimulation Either Prior to Or after Rapid Kindling Stimulation Inhibits the Kindling-Induced Epileptogenesis
Objective. Studies are ongoing to find appropriate low frequency stimulation (LFS) protocol for treatment of epilepsy. The present study aimed at assessing the antiepileptogenesis effects of LFS with the same protocol applied either just before or immediately after kindling stimulations. Method. This experimental animal study was conducted on adult Wistar rats (200 ± 20 g) randomly divided into...
متن کاملA Review on Chemical Induced Kindling Models of Epilepsy
A variety of animal models have been developed to study the effect of antiepileptic drugs. These models provide the means of inducing changes and causing alterations in neural function which may lead to epileptogenesis. Kindling is a lasting change in brain function caused by repeated stimulation resulting an increased seizure duration and progressive intensification of seizure activity. The ki...
متن کاملThe protective effect of auraptene against oxidative stress and pentylenetetrazol-induced chemical kindling in mice
It is believed that some pitfalls in the treatment of epilepsy including serious side effects of medications and drug resistance may be resolved by natural compounds. Auraptene is a natural coumarin that is found in many plants, particularly citrus peel. We hypothesized that auraptene might have anticonvulsant properties. Kindling was induced by repeated intraperitoneal (IP) injections of penty...
متن کاملDoes Conditioning Contribute to Kindling? 1 Does Inadvertent Conditioning Contribute to the Major Features of Kindling?
Conventional kindling experiments appear ideal for generating inadvertent conditioned effects: A variety of stimuli (e.g., removal from the home cage, attachment to the stimulation lead, and placement in the stimulation environment) are repeatedly presented to the animal prior to each stimulation and convulsion. We recently demonstrated that the stimulation environment can have a major impact o...
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ژورنال
عنوان ژورنال: Journal of the Japan Epilepsy Society
سال: 1988
ISSN: 0912-0890,1347-5509
DOI: 10.3805/jjes.6.138